Dimethyltryptamine (DMT)

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they've found that people have been using dmt for thousands of years. they think the Egyptians were big users of the stuff.

People have used all psychedelics for thousands of years, DMT just one among many. Mushrooms, cactus, blue lotus, manna, ayahasca, dmt etc

DMT is mostly traditionally used by South American indians. The usual way to take it is two guys sit opposite each other with pipes and spit it into each other's noses simultaneously. Thats because you need a big initial hit to 'go all the way' (cant snort that much on your own) and once you do you're in no state to communicate with those around you. Strassman describes this in his book.

here's another description:
There are several plant sources of DMT, many of which have uniquely different histories of use. Normally DMT is not active if taken orally. It must be either smoked or snorted for any psychoactive effects. To obtain a full strength DMT experience, one must take the entire dose into their system in a short period of time.

Two sources of DMT, Anadenanthera peregrina and Virola theiodora, are made into snuffs, commonly known as Yopo and Epena, respectively. The natives of the Amazon region have ingenious methods for getting a good dose of these snuffs. One method calls for a "snorter" through which they inhale with both nostrils at once. The most effective is a snorting device for two people. This device has a tube going from the mouth of each person to the nose of the other Rather than snorting, once the device is loaded, one person "blows'; the DMT snuff into the other's nose, getting a large amount deep into the nasal cavity. The person who received the first hit must quickly blow a dose into the other person's nose before falling into a tryptamine trance, "trypping."

Elsewhere in the Amazon, DMT-containing plants like Psychotria veridis are included in brews known as Ayahuasca or Yage. These brews include Banisteriopsis caapi, which is a source of Harmala alkaloids, and occasionally plants from the Belladonna family. The combination of Harmala alkaloids and DMT is amazing. The Harmala alkaloids intensify the DMT "tryp," and in my opinion produce a deeper, more spiritual experience. The Harmala alkaloids which are MAO inhibitors, also allow the DMT to be active when taken orally.
Lycaeum > Leda > The Essential Psychedelic Guide by D.M. Turner

These days its more commonly smoked. As described above ayahuasca is different and contains several compounds, including DMT, that intensify the trip. Its usually taken in a controlled environment with an experienced guide, where everyone sits with a spew bucket in front of them, as normally you vomit at the beginning of the trip. Not a recreational experience!
 
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