Almost a year without it



contract said:
Word..

~20mg daily over here. Which is a considerably small dose.. No side effects. ~1 year now.

Reading online though, and I have no idea how some people require 60mg-100mg+/daily of ritalin.
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I start off the day with 72 mg and usually will throw back another 36mg of Ritalin. I've done close to 200mg in a day but I started to get some cold sweats and caught myself peeking out my blinds a few times :1orglaugh:...but yeah, 108mg daily is good for me.
 
ptpatil said:
What are the long term effects? Because I've been taking 30s for 2 months now.
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elgordo said:
Can you point to a single medical case where moderate use of smart drugs (ritalin, adderall, etc) have caused liver issues? Because I was unable to locate even a single instance.

I've brought this up with multiple specialists because I've had a pretty big fear of physical damage after 10+ years of use, and they state the risk to my liver is almost nil.

Drinking alcohol and eating shitty processed food is much more harmful.

But taking a stack of non-reviewed nootropics (sp) every day is safer? No thanks :lol
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Never knew the liver was the concern here.

I'm not a fucking scientist so this isn't going to sound smart when I say it. However, I did a term paper and presentation on amphetamines in college so that means I'm an expert.

The gist behind my long term concern has been how it could potentially effect your long term dopamine production and uptake aka dopamine depletion. You know how you come down after a larger than normal dose of addy? Well what if after taking it for 5-10 years straight, you spend everyday with that "down" feeling?

Copied from Wikipedia:

The following is plagiarized from the Wikipedia article on Dopamine dysregulation syndrome: http://en.wikipedia.org/wiki/Dopamin...ation_syndrome

"In accordance with the role of dopamine in reward processing, addictive drugs stimulate dopamine release.[3] Although the exact mechanism has yet to be elucidated; the role of dopamine in the reward system and addiction has been proposed as the origin of DDS (Dopamine dysregulation syndrome).[3] Models of addiction have been used to explain how dopamine replacement therapy produces DDS.[4] One of this models of addiction proposes that over the usage course of a drug there is an habituation to the rewarding that it produces at the initial stages. This habituation is thought to be dopamine mediated. With a long-time administration of L-dopa the reward system gets used to it and needs higher quantities. As the user increases its drug intake there is a destruction of dopaminergic receptors in the striatum which acts in addition to an impairment in goal-direction mental functions to produce an enhancement of sensitization to dopamine therapy. The behavioral and mood symptoms of the syndrome are produced by the dopamine overdose.

The most common symptom is craving for dopaminergic medication. However other behavioral symptoms can appear independently of craving or co-occur with it.[4] Craving is an intense impulse of the subject to obtain medication even in the absence of symptoms that indicate its intake.[4] To fulfill this need the person will self-administer extra doses. When self administration is not possible aggressive outbursts or the use of strategies such as symptom simulation or bribery to access additional medication can also appear.[4]

Hypomania, manifesting with feelings of euphoria, omnipotence, or grandiosity, are prone to appear in those moments when medication effects are maximum; while dysphoria, characterized by sadness, psychomotor slowing, fatigue or apathy; are typical with DRT withdrawal.[4] Different impulse control disorders have been described including gambling, compulsive shopping, eating disorders and hypersexuality.[4] Behavioral disturbances; most commonly aggressive tendencies are the norm. Psychosis is also common.[4] Other possible symptom is punding, repetition of complex motor behaviors such as collecting or arranging objects."
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The tl;dr version:

Basically, it means medications like Adderall and Dex stimulate dopamine release in the brain. So the drug causes the brain to produce more dopamine, which activates your brain's reward system. But after awhile, the reward system gets used to the extra dopamine, and it needs even more to become activated. So you have to increase your dose just to get the same effects you got when you first started treatment. That's how people get addicted or become dependent on the drug. So when you stop taking the drug, your brain can't produce enough dopamine to activate the reward system. You now require the drug for normal brain functioning. That's Dopamine dysregulation syndrome.

There are some OTC drugs that can help combat dopamine depletion. L-Tyrosine and L-Trytophan to name a few.
The Dopamine Diet | The Dr. Oz Show

My mental health is more important to me than my physical health.
 
robbie222 said:
I start off the day with 72 mg and usually will throw back another 36mg of Ritalin. I've done close to 200mg in a day but I started to get some cold sweats and caught myself peeking out my blinds a few times :1orglaugh:...but yeah, 108mg daily is good for me.
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Yeah- that's too much for anyone. I take 15mg and 5mg. What you're doing is insane.
 
jhoffy22 said:
Never knew the liver was the concern here.

I'm not a fucking scientist so this isn't going to sound smart when I say it. However, I did a term paper and presentation on amphetamines in college so that means I'm an expert.

The gist behind my long term concern has been how it could potentially effect your long term dopamine production and uptake aka dopamine depletion. You know how you come down after a larger than normal dose of addy? Well what if after taking it for 5-10 years straight, you spend everyday with that "down" feeling?

Copied from Wikipedia:



The tl;dr version:

Basically, it means medications like Adderall and Dex stimulate dopamine release in the brain. So the drug causes the brain to produce more dopamine, which activates your brain's reward system. But after awhile, the reward system gets used to the extra dopamine, and it needs even more to become activated. So you have to increase your dose just to get the same effects you got when you first started treatment. That's how people get addicted or become dependent on the drug. So when you stop taking the drug, your brain can't produce enough dopamine to activate the reward system. You now require the drug for normal brain functioning. That's Dopamine dysregulation syndrome.

There are some OTC drugs that can help combat dopamine depletion. L-Tyrosine and L-Trytophan to name a few.
The Dopamine Diet | The Dr. Oz Show

My mental health is more important to me than my physical health.
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I've heard about the theory of a risk to dopamine production. Only thing is, Ritalin has been around for 50+ years and these effects have yet to be seen.
 
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