epharms are huge. You can probably make a killing doing media buys on places like drugbuyers.
Prob is, nearly every epharmacy is unreliable. I had a friend order something from a reputable dealer, and he literally received his product SIX MONTHS LATER.
There are actually very very lucrative drug markets that have near zero competition. They lie in a gray hat area. Selling research chemicals. Basically, most people aren't aware, but new drugs come out all the time.. not pharmaceauticals, but drugs that might or might not eventually become illegal (most don't), they have similar effects to acid, MDMA, etc. 2ci, bromo-dragonfly, methylone, etc.. are extremely popular.
One can "legally" import them from other countries (notably China and Germany) and sell here.. though you'd need to be careful how you promote the product.
canadaRC.ca is one company thats been around for years that does this. There was a huge bust of such sites a couple of years back - that's why you wont see many operate in the US, though I don't think any of the webmasters were prosecuted.
I had a friend who was selling 2CI offline .. made $5K a week. Eventually raised suspicion but got nothing more than a slap on the wrist. It *is* illegal to sell the product off as something else. Even trying to sell aspirin pills as vicodin would get you in trouble.
Anyway, there you go. It's not as illegal as getting caught selling drugs that *are* regulated/illicit, and there's virtually no competition, but its pricer and much harder to do.